Plasmin deficiency may lead to thrombosis , as clots are not adequately degraded. Plasminogen deficiency in mice leads to defective liver repair, [9] defective wound healing, reproductive abnormalities. [ citation needed ]

Arthritis treatment varies from person to person, depending on the cause, amount of damage to the joints, and how it affects daily activities. In the most severe cases, joint replacement surgery may be necessary. In most other cases, treatment focuses on reducing pain and inflammation while preventing further damage.

20 mcg/dose PO or 6 mcg/dose IV for dialysis patients three times per week for a maximum of 60 mcg/week PO or 18 mcg/week IV for dialysis patients; mcg/day PO for pre-dialysis patients.

Store Oncaspar® under refrigeration at 2°C to 8°C (36°F to 46°F). Do not shake or freeze product. Protect from light. Do not use Oncaspar® after the expiration date on the vial.

The technical details concerning the various muscle tissue acted upon by the enzymes is discussed in depth in Part VIL Chapter 27, “Applied Enzymology of Meat Texture Optimization” of the book entitled, Source Book of Food Enzymology, by Sigmund Schwimmer, . There are various opinions and approaches to the process of tenderizing meats. One is the antemortern use of meat tenderizing enzymes. This consists of the physical injection of a controlled solution of either papain or some other enzyme into the living animal. This practice has been discontinued and is no longer used. Postmortem application is generally acceptable for the lesser quality cuts and a variety of application methods are available. Often, the enzyme is included as part of a marinade.

Linus Pauling Institute | Oregon State University
307 Linus Pauling Science Center | Corvallis, Oregon 97331
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Passage of methotrexate from blood to the cerebrospinal fluid is minimal and for adequate therapy the drug should be administered intrathecally. Methotrexate may be given in a prophylactic regimen in all cases of lymphocytic leukaemia. The dose of intrathecal Methotrexate is constant regardless of age or body surface area in patients over the age of 3 years of age, the maximum intrathecal dose should be 12 mg in such patients. Patients under the age of 3 years should be treated in accordance with combination chemotherapy protocols. The administration is at weekly intervals and is usually repeated until the cell count of cerebrospinal fluid returns to normal. At this point one additional dose is advised. Large doses may cause convulsions and untoward side effects may occur as with any intrathecal injection, and are commonly neurological in character.

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